Occupational factors and risk of Parkinson's disease: A population-based case-control study

Am J Ind Med. 2010 Mar;53(3):217-23. doi: 10.1002/ajim.20788.


Background: Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent.

Objective: To estimate the risk of PD associated with various jobs and workplace exposures.

Methods: We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression.

Results: Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents.

Conclusions: These findings do not provide support for the hypothesis that workplace factors affect the risk of PD.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Confidence Intervals
  • Female
  • Hazardous Substances / toxicity
  • Humans
  • Incidence
  • Industry / classification
  • Male
  • Middle Aged
  • Occupational Diseases / epidemiology
  • Occupational Diseases / etiology*
  • Occupational Exposure / adverse effects*
  • Odds Ratio
  • Parkinson Disease / epidemiology
  • Parkinson Disease / etiology*
  • Pesticides / adverse effects
  • Risk Assessment
  • Risk Factors
  • Surveys and Questionnaires
  • Washington / epidemiology
  • Workplace


  • Hazardous Substances
  • Pesticides