Cardiac diastolic dysfunction and metabolic syndrome in young women after placental syndrome

Obstet Gynecol. 2010 Jan;115(1):101-108. doi: 10.1097/AOG.0b013e3181c4f1e8.


Objective: To estimate whether women with a recent history of a placental syndrome and concomitant metabolic syndrome have reduced cardiac diastolic function.

Methods: In this cohort study, women with a history of a placental syndrome were included. We assessed body mass index, blood pressure, fasting serum lipids, glucose and insulin levels, and 24-hour urinary protein and albumin output after an interval of at least 6 months postpartum. Cardiac diastolic function was assessed by echocardiography.

Results: Metabolic syndrome was found in 22% of the women evaluated. Diastolic dysfunction was seen in 24% of the women with the metabolic syndrome compared with 6.3% in those without (odds ratio 4.77, 95% confidence interval 2.18-10.41; adjusted odds ratio 6.09, 95% confidence interval 2.64-14.04). Univariable analysis showed that all the constituents of the metabolic syndrome related to diastolic dysfunction.

Conclusion: In women with a history of placental syndrome complicating pregnancy, the presence of metabolic syndrome increases the risk of cardiac diastolic dysfunction fourfold.

Level of evidence: II.

MeSH terms

  • Adult
  • Comorbidity
  • Diastole / physiology
  • Female
  • Fetal Growth Retardation / epidemiology
  • Humans
  • Hyperinsulinism / epidemiology
  • Metabolic Syndrome
  • Placenta Diseases / epidemiology*
  • Placenta Diseases / physiopathology*
  • Pre-Eclampsia / epidemiology
  • Pregnancy
  • Prognosis
  • Ventricular Dysfunction / epidemiology*
  • Ventricular Dysfunction / physiopathology*