Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease

Bull Exp Biol Med. 2009 Aug;148(2):343-5. doi: 10.1007/s10517-009-0682-0.


The study demonstrated high anxiolytic activity of tenoten, which was not inferior to the anxiolytic effect of grandaxin. The positive changes persisted after termination of treatment in the tenoten group (but not in grandaxin group). Tenoten can be recommended for the treatment of patients with cardiovascular diseases associated with neurotic disturbances.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Anxiety Agents / therapeutic use
  • Antibodies / therapeutic use*
  • Antihypertensive Agents / therapeutic use*
  • Anxiety / drug therapy*
  • Anxiety / pathology
  • Benzodiazepines / therapeutic use*
  • Coronary Disease / complications*
  • Female
  • Humans
  • Hypertension / complications*
  • Male
  • Middle Aged
  • Treatment Outcome


  • Anti-Anxiety Agents
  • Antibodies
  • Antihypertensive Agents
  • tenoten
  • Benzodiazepines
  • tofisopam