Protein E of Haemophilus Influenzae Is a Ubiquitous Highly Conserved Adhesin

J Infect Dis. 2010 Feb 1;201(3):414-9. doi: 10.1086/649782.


Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Bacterial / metabolism*
  • Amino Acid Sequence
  • Base Sequence
  • Conserved Sequence
  • Genes, Bacterial
  • Haemophilus influenzae / metabolism*
  • Molecular Sequence Data
  • Phylogeny


  • Adhesins, Bacterial