The Association of African Ancestry and Elevated Creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Am J Nephrol. 2010;31(3):202-8. doi: 10.1159/000268955. Epub 2009 Dec 21.

Abstract

Whether genetic factors account for differences in early kidney disease among blacks in a young healthy population is not well known. We evaluated the association of self-reported race and genetic African ancestry with elevated creatinine (> or =1.3 mg/dl for men, > or =1.1 mg/dl for women) among 3,113 black and white participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, ages 38-50 years. We estimated individual African ancestry using 42 ancestry informative markers. Blacks were more likely to have elevated creatinine than whites, and this effect was more pronounced in men: adjusted odds ratio (AOR) for black versus white men = 7.03, 4.15-11.91; AOR for women = 2.40, 1.15-5.02. Higher African ancestry was independently associated with elevated creatinine among black men (AOR = 1.53,1.08-2.16 per SD increase in African ancestry), but not women. A graded increase in odds of elevated creatinine by African Ancestry was observed among black men compared with white men: AOR = 4.27 (2.26-10.06) for black men with 40-70% African ancestry; AOR = 8.09 (4.19-15.61) for black men with 70-80% African ancestry; AOR = 9.05 (4.81-17.02) for black men with >80% African ancestry. Genetic factors common to African ancestry may be associated with increased risk of early kidney dysfunction in a young, healthy population, particularly among black men.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • African Continental Ancestry Group / genetics
  • African Continental Ancestry Group / statistics & numerical data*
  • Cohort Studies
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / ethnology*
  • Coronary Artery Disease / genetics
  • Creatinine / blood*
  • European Continental Ancestry Group / genetics
  • European Continental Ancestry Group / statistics & numerical data*
  • Female
  • Genetic Markers
  • Humans
  • Incidence
  • Kidney Diseases / blood
  • Kidney Diseases / ethnology
  • Kidney Diseases / genetics
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Risk Factors
  • Sex Distribution
  • Young Adult

Substances

  • Genetic Markers
  • Creatinine