Central leptin receptor action and resistance in obesity

J Investig Med. 2009 Oct;57(7):789-94. doi: 10.2310/JIM.0b013e3181bb0d49.


The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiology
  • Drug Resistance / genetics
  • Leptin / physiology
  • Obesity / genetics
  • Obesity / physiopathology*
  • Pro-Opiomelanocortin / physiology
  • Receptors, Leptin / genetics
  • Receptors, Leptin / physiology*
  • Signal Transduction


  • Leptin
  • Receptors, Leptin
  • Pro-Opiomelanocortin