Emerging roles of ATF2 and the dynamic AP1 network in cancer

Nat Rev Cancer. 2010 Jan;10(1):65-76. doi: 10.1038/nrc2681.


Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Activating Transcription Factor 2 / genetics
  • Activating Transcription Factor 2 / metabolism*
  • Animals
  • Gene Regulatory Networks*
  • Humans
  • Multigene Family
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Protein Binding
  • Proto-Oncogene Proteins c-jun / genetics
  • Proto-Oncogene Proteins c-jun / metabolism
  • Transcription Factor AP-1 / genetics
  • Transcription Factor AP-1 / metabolism*


  • Activating Transcription Factor 2
  • Proto-Oncogene Proteins c-jun
  • Transcription Factor AP-1