Post-transcriptional regulons coordinate the initiation and resolution of inflammation

Nat Rev Immunol. 2010 Jan;10(1):24-35. doi: 10.1038/nri2685.


Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / immunology*
  • Humans
  • Inflammation / genetics*
  • Inflammation / immunology*
  • Protein Biosynthesis / genetics
  • Protein Biosynthesis / immunology*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • RNA, Messenger / immunology
  • Regulon / genetics
  • Regulon / immunology*
  • Transcription, Genetic / genetics
  • Transcription, Genetic / immunology*


  • RNA, Messenger