Animal models of neuropathic pain

Fundam Clin Pharmacol. 2011 Feb;25(1):1-28. doi: 10.1111/j.1472-8206.2009.00801.x.


Animal models are pivotal for understanding the mechanism of neuropathic pain and development of effective therapy for its optimal management. A battery of neuropathic pain models has been developed to simulate the clinical pain conditions with diverse etiology. The present review exhaustively discusses the methodology, behavioral alterations, limitations, and advantages of about 40 different animal models of neuropathic pain along with their modifications. Development of these models has contributed immensely in understanding the chronic pain and underlying peripheral as well as central pathogenic mechanisms. Furthermore, research has resulted in the development of new therapeutic agents for neuropathic pain management, and the preclinical data obtained using these animal models have been successively translated to effective pain management in clinical setup also. As each animal model has been created with specific methodology and results tend to vary largely with the slight changes related to methodology, therefore, it is essential that data from different models should be reported and interpreted in the context of the specific pain model.

Publication types

  • Review

MeSH terms

  • Analgesics / pharmacology*
  • Animals
  • Behavior, Animal
  • Disease Models, Animal*
  • Drug Design
  • Drug Evaluation, Preclinical / methods
  • Humans
  • Neuralgia / drug therapy
  • Neuralgia / etiology
  • Neuralgia / physiopathology*


  • Analgesics