Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter Baumannii

Emerg Infect Dis. 2010 Jan;16(1):35-40. doi: 10.3201/eid1601.090852.

Abstract

To assess dissemination of OXA-23-producing strains of Acinetobacter baumannii, we obtained 20 carbapenem-resistant, OXA-23-producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The blaOXA-23 gene was either located on the chromosome or on plasmids and associated with 4 genetic structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / diet therapy
  • Acinetobacter Infections / epidemiology
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology
  • Acinetobacter baumannii / genetics*
  • Blotting, Southern
  • Cloning, Molecular
  • Electrophoresis, Gel, Pulsed-Field
  • Gene Transfer, Horizontal / genetics
  • Genes, Bacterial / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics*

Substances

  • beta-lactamase OXA-23
  • beta-Lactamases

Associated data

  • GENBANK/EF059914
  • GENBANK/EF127491
  • GENBANK/GQ861438
  • GENBANK/GQ861439