Chemical mutagenesis and fine-structure functional analysis of the mouse genome

Trends Genet. 1991 Jan;7(1):15-21. doi: 10.1016/0168-9525(91)90016-j.


Heritable mutations constitute important raw materials for mammalian developmental genetics and general genome studies. Mutations induced by high-efficiency chemical mutagenesis of germ cells in mice can be used in genetic and molecular studies to complement physical-mapping strategies and to examine the nature and extent of the functional complexities hidden within the mammalian genome.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping / methods*
  • Genes / physiology*
  • Germ Cells / drug effects
  • Germ Cells / radiation effects
  • Mice / genetics
  • Mutagenesis / genetics*