Anti N1 cross-protecting antibodies against H5N1 detected in H1N1 infected people

Curr Microbiol. 2010 Jul;61(1):25-8. doi: 10.1007/s00284-009-9571-z. Epub 2009 Dec 25.


The A(H5N1) influenza virus pandemic may be the result of avian H5N1 adapting to humans, leading to massive human to human transmission in a context of a lack of pre-existing immunity. As A(H1N1) and A(H5N1) share the same neuraminidase subtype, anti-N1 antibodies subsequent to H1N1 infections or vaccinations may confer some protection against A(H5N1). We analysed, by microneutralization assay, the A/Vietnam/1194/04 (H5N1) anti-N1 cross-protection acquired either during A/New-Caledonia/20/99 (H1N1) infection or vaccination. In cases with documented H1N1 infection, H5N1 cross-protection could be observed only in patients born between 1930 and 1950. No such protection was detected in the sera of vaccinated individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / immunology
  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Cross Protection*
  • Humans
  • Influenza A Virus, H1N1 Subtype / immunology*
  • Influenza A Virus, H5N1 Subtype / immunology*
  • Influenza Vaccines / immunology
  • Influenza, Human / immunology*
  • Influenza, Human / prevention & control
  • Influenza, Human / virology
  • Middle Aged
  • Neuraminidase / immunology*
  • Neutralization Tests
  • Vaccination
  • Young Adult


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Influenza Vaccines
  • Neuraminidase