Abstract
Objective:
To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.
Methods:
The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.
Results:
The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.
Conclusion:
The pellets have sustained-release effect in 12 hours.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins
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Benzyl Alcohols / analysis
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Benzyl Alcohols / chemistry*
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Benzyl Alcohols / pharmacokinetics
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Delayed-Action Preparations*
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Drug Carriers
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacokinetics
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Gastrodia / chemistry*
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Glucosides / analysis
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Glucosides / chemistry*
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Glucosides / pharmacokinetics
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Microspheres
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Plants, Medicinal / chemistry
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Polymers / chemistry
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Solubility
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Technology, Pharmaceutical / instrumentation
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Technology, Pharmaceutical / methods*
Substances
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Acrylic Resins
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Benzyl Alcohols
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Delayed-Action Preparations
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Drug Carriers
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Drugs, Chinese Herbal
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Glucosides
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Polymers
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Eudragit RS
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gastrodin