[Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed coating]

Zhong Yao Cai. 2009 Sep;32(9):1444-7.
[Article in Chinese]

Abstract

Objective: To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.

Methods: The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.

Results: The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.

Conclusion: The pellets have sustained-release effect in 12 hours.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins
  • Benzyl Alcohols / analysis
  • Benzyl Alcohols / chemistry*
  • Benzyl Alcohols / pharmacokinetics
  • Delayed-Action Preparations*
  • Drug Carriers
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacokinetics
  • Gastrodia / chemistry*
  • Glucosides / analysis
  • Glucosides / chemistry*
  • Glucosides / pharmacokinetics
  • Microspheres
  • Plants, Medicinal / chemistry
  • Polymers / chemistry
  • Solubility
  • Technology, Pharmaceutical / instrumentation
  • Technology, Pharmaceutical / methods*

Substances

  • Acrylic Resins
  • Benzyl Alcohols
  • Delayed-Action Preparations
  • Drug Carriers
  • Drugs, Chinese Herbal
  • Glucosides
  • Polymers
  • Eudragit RS
  • gastrodin