Management of massive osteolysis of the mandible: a case report

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):238-41. doi: 10.1016/j.tripleo.2009.08.044.


The management of a previously reported case of massive osteolysis of the mandible with intravenous bisphosphonate, vascularized free bone graft, and dental implants is reported. Restoration of adequate cosmetics and masticatory function was achieved. Despite the use of bisphosphonates, there were no complications with osseointegration. The reconstruction remained stable and functional 6 years afterward.

Publication types

  • Case Reports

MeSH terms

  • Bone Density Conservation Agents / therapeutic use*
  • Bone Transplantation
  • Child
  • Dental Implantation, Endosseous / methods*
  • Dental Prosthesis, Implant-Supported
  • Diphosphonates / therapeutic use*
  • Female
  • Fibula / surgery
  • Humans
  • Mandibular Diseases / therapy*
  • Osteolysis, Essential / therapy*
  • Pamidronate
  • Surgical Flaps / blood supply*


  • Bone Density Conservation Agents
  • Diphosphonates
  • Pamidronate