Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1

FEBS Lett. 2010 May 17;584(10):2028-32. doi: 10.1016/j.febslet.2009.12.035. Epub 2009 Dec 24.


Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Channels / chemistry*
  • Calcium Channels / metabolism*
  • Electric Conductivity
  • Intracellular Space / metabolism*
  • Phenotype
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins / chemistry*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • TRPC Cation Channels
  • Transient Receptor Potential Channels / chemistry*
  • Transient Receptor Potential Channels / metabolism*


  • Calcium Channels
  • Saccharomyces cerevisiae Proteins
  • TRPC Cation Channels
  • Transient Receptor Potential Channels
  • Yvc1 protein, S cerevisiae