Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

Drug Discov Today. 2010 Feb;15(3-4):102-14. doi: 10.1016/j.drudis.2009.12.003. Epub 2009 Dec 24.


Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Disease Progression
  • Humans
  • Molecular Imaging / methods*
  • Neoplasms / diagnosis
  • Neoplasms / diagnostic imaging*
  • Neoplasms / metabolism
  • Radionuclide Imaging
  • Translational Medical Research / methods*
  • Validation Studies as Topic


  • Biomarkers, Tumor