The geoepidemiology of systemic lupus erythematosus

Autoimmun Rev. 2010 Mar;9(5):A277-87. doi: 10.1016/j.autrev.2009.12.008. Epub 2009 Dec 24.

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold clinical manifestations and immunological abnormalities, affecting primarily women. Although accurate current data on its incidence and prevalence are largely lacking, there are numerous indications that SLE is far less common in Europeans and their descendants compared to all other ethnicities. The clinical manifestations of the disease show geographic or ethnic variation, generally being less severe in patients of European ancestry than in African, Asian, certain "Hispanic" or mestizo, and various indigenous populations. In particular, renal involvement is far more common in non-European patients. Genetic as well as environmental, sociodemographic and sociocultural factors are likely to contribute to the differences in the incidence and clinical expression of SLE.

Publication types

  • Review

MeSH terms

  • African Continental Ancestry Group / genetics
  • Asian Continental Ancestry Group / genetics
  • Autoimmune Diseases / genetics
  • Continental Population Groups / genetics
  • Ethnic Groups / genetics
  • European Continental Ancestry Group / genetics
  • Female
  • Hispanic Americans / genetics
  • Humans
  • Incidence
  • Lupus Erythematosus, Systemic / epidemiology*
  • Lupus Erythematosus, Systemic / genetics*
  • Prevalence