High flow nasal cannulae therapy in infants with bronchiolitis

J Pediatr. 2010 Apr;156(4):634-8. doi: 10.1016/j.jpeds.2009.10.039. Epub 2009 Dec 29.


Objectives: To determine whether the introduction of heated humidified high-flow nasal cannulae (HFNC) therapy was associated with decreased rates of intubation for infants <24 months old with bronchiolitis admitted to a pediatric intensive care unit (PICU).

Study design: A retrospective chart review of infants with bronchiolitis admitted before and in the season after introduction of HFNC.

Results: In the season after the introduction of HFNC, only 9% of infants admitted to the PICU with bronchiolitis required intubation, compared with 23% in the prior season (P=.043). This 68% decrease in need for intubation persisted in a logistic regression model controlling for age, weight, and RSV status. HFNC therapy resulted in a greater decrease in respiratory rate compared with other forms of respiratory support, and those infants with the greatest decrease in respiratory rate were least likely to be intubated. In addition, median PICU length of stay for children with bronchiolitis decreased from 6 to 4 days after the introduction of HFNC.

Discussion: We hypothesize that HFNC decreases rates of intubation in infants with bronchiolitis by decreasing the respiratory rate and work of breathing by providing a comfortable and well-tolerated means of noninvasive ventilatory support.

Publication types

  • Comparative Study

MeSH terms

  • Bronchiolitis / therapy*
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Hot Temperature
  • Humans
  • Humidity
  • Infant
  • Infant, Newborn
  • Intensive Care Units, Pediatric
  • Male
  • Nose
  • Oxygen Inhalation Therapy / instrumentation*
  • Retrospective Studies
  • Treatment Outcome