Two chaperonin systems in bacterial genomes with distinct ecological roles

Trends Genet. 2010 Feb;26(2):47-51. doi: 10.1016/j.tig.2009.11.009. Epub 2009 Dec 28.

Abstract

Bacterial chaperonins are essential to cell viability and have a role in endosymbiosis, which leads to increased biological complexity. However, the extent to which chaperonins promote ecological innovation is unknown. We screened 622 bacterial genomes for genes encoding chaperonins, and found archaeal-like chaperonins in bacteria that inhabit archaeal ecological niches. We found that chaperonins encoded in pathogenic bacteria are the most functionally divergent. We identified the molecular basis of the dramatic structural changes in mitochondrial GROEL, a highly derived chaperonin gene. Our analysis suggests that chaperonins are important capacitors of evolutionary and ecological change.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / chemistry
  • Bacteria / cytology
  • Bacteria / genetics*
  • Bacteria / metabolism
  • Chaperonins / chemistry
  • Chaperonins / genetics*
  • Chaperonins / metabolism
  • Ecosystem*
  • Evolution, Molecular
  • Genome, Bacterial*
  • Humans
  • Microbial Viability

Substances

  • Chaperonins