Inflammation and oncogenesis: a vicious connection

Curr Opin Genet Dev. 2010 Feb;20(1):65-71. doi: 10.1016/j.gde.2009.11.004. Epub 2009 Dec 25.


Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Colitis / metabolism
  • Humans
  • Inflammation / complications*
  • Inflammation Mediators / immunology
  • NF-kappa B / metabolism
  • Neoplasms / congenital
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction


  • Inflammation Mediators
  • NF-kappa B
  • STAT3 Transcription Factor