Growth Factors in Tumor Microenvironment

Front Biosci (Landmark Ed). 2010 Jan 1;15:151-65. doi: 10.2741/3612.


Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also discusses how deregulation of these growth factors or their receptors can drive malignant transformation and progression.

Publication types

  • Review

MeSH terms

  • Animals
  • Epidermal Growth Factor / metabolism*
  • ErbB Receptors / metabolism
  • Fibroblast Growth Factors / metabolism*
  • Humans
  • Models, Biological
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Platelet-Derived Growth Factor / metabolism*
  • Receptors, Fibroblast Growth Factor / metabolism
  • Receptors, Platelet-Derived Growth Factor / metabolism


  • Platelet-Derived Growth Factor
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Epidermal Growth Factor
  • ErbB Receptors
  • Receptors, Platelet-Derived Growth Factor