Chemokine patterning by glycosaminoglycans and interceptors

Front Biosci (Landmark Ed). 2010 Jan 1;15:645-60. doi: 10.2741/3638.


Chemokines mediate leukocyte emigration from blood into tissues. This process is triggered by chemokines binding and signaling through their cognate G-protein-coupled receptors on leukocytes and requires the involvement of leukocyte and endothelial cell adhesion molecules. Additionally, in vivo chemokine activity depends on their interaction with "auxiliary" molecules expressed by the vascular endothelial cells. Secreted chemokines can be immobilized on the luminal and abluminal endothelial cell surfaces by glycosaminoglycans. In order to be targeted to their presentation sites on the luminal endothelial cell surface, the tissue-derived chemokines have to cross the endothelial cell barrier. For inflammatory chemokines this is accomplished by active transport involving Duffy antigen, an 'interceptor' expressed by venular endothelial cells. Other chemokine interceptors, D6 in particular, may act as scavenging decoys and are involved in clearance of chemokines. The interceptor-mediated transport or elimination of chemokines, together with their immobilization by glycosaminoglycans, lead to chemokine patterning at the blood-tissue interface and within tissues. The resulting chemokine gradients induce leukocyte emigration from blood and may also be necessary for directed leukocyte migration within tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Chemokine CXCL11 / metabolism
  • Chemokine CXCL12 / metabolism
  • Chemokines / metabolism*
  • Glycosaminoglycans / metabolism*
  • Humans
  • Leukocytes / cytology
  • Leukocytes / physiology
  • Protein Binding
  • Receptors, CCR10 / metabolism
  • Receptors, CXCR / metabolism
  • Receptors, Chemokine / metabolism*


  • ACKR3 protein, human
  • Chemokine CXCL11
  • Chemokine CXCL12
  • Chemokines
  • Glycosaminoglycans
  • Receptors, CCR10
  • Receptors, CXCR
  • Receptors, Chemokine
  • chemokine receptor D6