Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy

Front Biosci (Elite Ed). 2010 Jan 1;2:36-42. doi: 10.2741/e62.


Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemic-encephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33 per cent and a specificity of 96.63 per cent, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs.

MeSH terms

  • Activins / blood*
  • Analysis of Variance
  • Asphyxia Neonatorum / blood*
  • Case-Control Studies
  • Cerebrum / diagnostic imaging
  • Humans
  • Hypoxia-Ischemia, Brain / blood
  • Hypoxia-Ischemia, Brain / diagnosis*
  • Infant, Newborn
  • Sensitivity and Specificity
  • Statistics, Nonparametric
  • Ultrasonography


  • activin A
  • Activins