Emerging role of resveratrol in the treatment of severe acute pancreatitis

Front Biosci (Schol Ed). 2010 Jan 1;2:168-75. doi: 10.2741/s54.

Abstract

Severe acute pancreatitis (SAP) develops in 15-20% of patients with acute pancreatitis. The management of SAP is a challenging task owing to the fact that it can lead to morbid conditions like multiple organ failure and systemic inflammatory response syndrome, if left untreated. Resveratrol, a drug used in Chinese traditional medicine has shown potential to treat many symptoms of SAP due to its multiple physiological actions. It possesses anti-inflammatory and anti-oxidative properties, both of which are essential in SAP. NF-kappaB activation is a major source of pro-inflammatory mediators in SAP. Administration of resveratrol can inhibit NF-kappaB activity as well as reduce the concentrations of TNF-alpha, IL-6 and IL-1. It can also scavenge reactive oxygen species that are capable of extensive tissue damage. Furthermore, resveratrol also exhibits anti-apoptotic properties via regulation of apoptotic mediators such as Bax, Bcl-2, and caspase-3. It also plays a role in calcium regulation and alleviates SAP-induced histopathological distortions in the pancreas. These multi-faceted results support the use of resveratrol in SAP and mandate the need for extensive research on this molecule.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Apoptosis / drug effects*
  • Caspase 3 / metabolism
  • Cytokines / metabolism
  • Humans
  • Interleukin-1 / metabolism
  • Interleukin-6 / metabolism
  • NF-kappa B / antagonists & inhibitors
  • Pancreatitis, Acute Necrotizing / drug therapy*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Reactive Oxygen Species / metabolism
  • Resveratrol
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use*
  • Tumor Necrosis Factor-alpha / metabolism
  • bcl-2-Associated X Protein / metabolism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Cytokines
  • Interleukin-1
  • Interleukin-6
  • NF-kappa B
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Stilbenes
  • Tumor Necrosis Factor-alpha
  • bcl-2-Associated X Protein
  • Caspase 3
  • Resveratrol