Bioclinical markers in breast cancer: updates and perspectives

Front Biosci (Schol Ed). 2010 Jan 1;2:343-58. doi: 10.2741/s69.


Molecular studies have definitely changed our knowledge of the biology of cancers, and breast cancer's tremendous social impact has stimulated a large mass of research. Classic markers have opened a road, but their usefulness appears limited to prognosis or follow up, while several new markers, both genetic and molecular, are assuming different, yet still controversial, importance: they may play a major role in the surveillance of subjects at risk, in detecting primary or recurrent cancers, and in predicting the need of adjuvant therapy, or the response to therapy. .

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Cytokines / metabolism
  • DNA Adducts / metabolism
  • Drug Delivery Systems / methods
  • Early Detection of Cancer / methods*
  • Estrogens / metabolism
  • Female
  • Humans


  • Biomarkers, Tumor
  • Cytokines
  • DNA Adducts
  • Estrogens