Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

Nephrol Dial Transplant. 2010 Apr;25(4):1335-7. doi: 10.1093/ndt/gfp682. Epub 2009 Dec 27.

Abstract

Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D(3)), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D(3)-1alpha-hydroxylase, could explain the deficiency of 1,25(OH)(2)D(3) in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

Publication types

  • Case Reports

MeSH terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / deficiency
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / metabolism*
  • Fibroblast Growth Factors / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Rhabdomyolysis / complications*
  • Rhabdomyolysis / metabolism
  • Vitamin D / analogs & derivatives
  • Vitamin D / metabolism

Substances

  • Vitamin D
  • Fibroblast Growth Factors
  • fibroblast growth factor 23
  • 25-hydroxyvitamin D
  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase