Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Nat Methods. 2010 Feb;7(2):126-9. doi: 10.1038/nmeth.1412. Epub 2009 Dec 27.


Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Biosensing Techniques / instrumentation*
  • Dopamine / analysis*
  • Electrochemistry / instrumentation*
  • Electrodes, Implanted*
  • Equipment Design
  • Equipment Failure Analysis
  • Mesencephalon / physiology*
  • Mice
  • Microelectrodes
  • Miniaturization
  • Monitoring, Ambulatory / instrumentation*
  • Neurotransmitter Agents / analysis
  • Rats
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Neurotransmitter Agents
  • Dopamine