Abstract
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biofilms / drug effects*
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Biofilms / growth & development
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Humans
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Microbial Sensitivity Tests
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Microscopy, Confocal
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Periodontitis / microbiology
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Plankton / drug effects
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Porphyromonas gingivalis / drug effects*
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Porphyromonas gingivalis / growth & development
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Porphyromonas gingivalis / ultrastructure
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Pyrantel / analogs & derivatives*
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Pyrantel / pharmacology
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Succinate Dehydrogenase / antagonists & inhibitors*
Substances
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Pyrantel
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oxantel
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Succinate Dehydrogenase