Life threatening protamine reaction during bypass surgery--a case report

Indian Heart J. 2009 Mar-Apr;61(2):216-7.

Abstract

An anaphylactic reaction to protamine sulphate during cardiac surgery is a rare but known entity. Preoperative prediction and outcome of such a reaction is still unclear. We report a case of severe anaphylactic reaction to protamine sulphate in a diabetic while performing beating heart bypass surgery. We also reviewed the literature and discussed the management of such cases.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anaphylaxis / therapy
  • Coronary Artery Bypass, Off-Pump / adverse effects*
  • Fatal Outcome
  • Heparin Antagonists / adverse effects*
  • Humans
  • Intraoperative Complications / chemically induced*
  • Intraoperative Complications / therapy
  • Male
  • Middle Aged
  • Protamines / adverse effects*
  • Risk Factors

Substances

  • Heparin Antagonists
  • Protamines