Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells

J Nat Prod. 2010 Feb 26;73(2):172-6. doi: 10.1021/np900578h.

Abstract

Four new lanostane triterpenes, butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4), were isolated from the fruiting bodies of Ganoderma lucidum together with 14 known compounds (5-18). The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects
  • Adipocytes / metabolism*
  • Animals
  • Fruiting Bodies, Fungal / chemistry
  • Japan
  • Lanosterol / analogs & derivatives*
  • Lanosterol / chemistry
  • Lanosterol / isolation & purification*
  • Lanosterol / pharmacology*
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Reishi / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • Triterpenes
  • Lanosterol