Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one year after therapy discontinuation

Dermatol Online J. 2009 Dec 15;15(12):15.


Hydroxychloroquine (HCQ) was initially indicated for the treatment of malaria, but more recently its anti-inflammatory and immune modulating properties have been utilized for treatment of multiple dermatologic and rheumatologic diseases. Mucocutaneous bluish-gray dyschromia is a rare side effect with HCQ and little information exists regarding its duration after drug discontinuation. The few existing case reports primarily describe small focal areas of discoloration. More extensive dyschromia has very rarely been reported with HCQ. We report a case of HCQ induced dyschromia diffusely involving the extremities, with minimal resolution one year after treatment discontinuation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Hydroxychloroquine / administration & dosage
  • Hydroxychloroquine / adverse effects*
  • Hyperpigmentation / chemically induced*
  • Time Factors


  • Hydroxychloroquine