Comorbidity and confounding in end-stage renal disease

Kidney Int. 2010 Jan;77(2):83-5. doi: 10.1038/ki.2009.431.


In the epidemiologic study of end-stage renal disease (ESRD), accurate adjustment for comorbidity is essential to controlling bias in the comparison of outcomes across groups of patients or dialysis facilities. Liu et al. derive and validate a novel comorbidity index using data from the United States Renal Data System. This novel index represents an important tool for observational research in ESRD but will not by itself overcome the potential problems of residual and unmeasured confounding in observational research.

Publication types

  • Comment

MeSH terms

  • Comorbidity*
  • Confounding Factors, Epidemiologic
  • Humans
  • Kidney Failure, Chronic / epidemiology*
  • Kidney Failure, Chronic / mortality*
  • Severity of Illness Index
  • Survival Analysis
  • Validation Studies as Topic