Hydrogen: another gas with therapeutic potential

Kidney Int. 2010 Jan;77(2):85-7. doi: 10.1038/ki.2009.432.


Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antioxidants / therapeutic use*
  • Hydrogen / therapeutic use*
  • Kidney Transplantation / adverse effects*
  • Renal Insufficiency, Chronic / etiology
  • Renal Insufficiency, Chronic / prevention & control*


  • Antioxidants
  • Hydrogen