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. 2010 Mar;91(3):712-21.
doi: 10.3945/ajcn.2009.28474. Epub 2009 Dec 30.

Intakes of Meat, Fish, Poultry, and Eggs and Risk of Prostate Cancer Progression

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Free PMC article

Intakes of Meat, Fish, Poultry, and Eggs and Risk of Prostate Cancer Progression

Erin L Richman et al. Am J Clin Nutr. .
Free PMC article

Abstract

Background: Processed meat and fish have been shown to be associated with the risk of advanced prostate cancer, but few studies have examined diet after prostate cancer diagnosis and risk of its progression.

Objective: We examined the association between postdiagnostic consumption of processed and unprocessed red meat, fish, poultry, and eggs and the risk of prostate cancer recurrence or progression.

Design: We conducted a prospective study in 1294 men with prostate cancer, without recurrence or progression as of 2004-2005, who were participating in the Cancer of the Prostate Strategic Urologic Research Endeavor and who were followed for an average of 2 y.

Results: We observed 127 events (prostate cancer death or metastases, elevated prostate-specific antigen concentration, or secondary treatment) during 2610 person-years. Intakes of processed and unprocessed red meat, fish, total poultry, and skinless poultry were not associated with prostate cancer recurrence or progression. Greater consumption of eggs and poultry with skin was associated with 2-fold increases in risk in a comparison of extreme quantiles: eggs [hazard ratio (HR): 2.02; 95% CI: 1.10, 3.72; P for trend = 0.05] and poultry with skin (HR: 2.26; 95% CI: 1.36, 3.76; P for trend = 0.003). An interaction was observed between prognostic risk at diagnosis and poultry. Men with high prognostic risk and a high poultry intake had a 4-fold increased risk of recurrence or progression compared with men with low/intermediate prognostic risk and a low poultry intake (P for interaction = 0.003).

Conclusions: Our results suggest that the postdiagnostic consumption of processed or unprocessed red meat, fish, or skinless poultry is not associated with prostate cancer recurrence or progression, whereas consumption of eggs and poultry with skin may increase the risk.

Figures

FIGURE 1
FIGURE 1
Relative risk of prostate cancer progression by prognostic risk and postdiagnostic consumption of poultry among 1294 men with prostate cancer in the Diet and Lifestyle substudy of CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor, 2004–2008). P for interaction = 0.003 derived by using a Wald test of the coefficient of the cross-product term between poultry and prognostic risk in a Cox proportional hazards regression model adjusted for the main effects of poultry and prognostic risk (low/intermediate compared with high), age at diagnosis, energy intake, time from diagnosis to questionnaire, Gleason sum at diagnosis, prostate-specific antigen at diagnosis, primary treatment, BMI, and nonvigorous activity. ▪, high prognostic risk (prostate-specific antigen >20 ng/mL or Gleason sum = 8–10 or T stage T3a+); n = 200 participants (49 events). ♦ , low/intermediate prognostic risk; n = 1065 participants (73 events). Prognostic risk was missing for 29 participants (5 events).

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