Objective: To investigate the impact of embryo replacement depth on IVF and embryo transfer outcomes.
Design: Retrospective analysis (May 2005 to November 2008) of 5,055 ultrasound-guided embryo transfers belonging to 3,930 infertile couples. The distance between the fundal endometrial surface and the catheter tip was measured and accordingly, patients were divided into five groups.
Setting: Anatolia IVF Center, Ankara, Turkey.
Patient(s): All patients enrolled in the IVF program undergoing embryo transfer.
Intervention(s): No patient received any additional procedure or intervention.
Main outcome measure(s): Clinical pregnancy rate (PR) and ongoing PR.
Result(s): Mean total number of embryos transferred in groups 4 and 5 were significantly higher than in groups 2 and 3. Analysis of PRs and outcome of gestations in the five groups studied yielded similar PRs in all groups except for group 1.
Conclusion(s): Pregnancy rates and ongoing PRs are higher if the embryos are replaced at a distance >10 mm from the fundal endometrial surface. In addition because significantly more embryos were replaced in cycles where the transfers occurred at a distance of >20 mm, a distance>10 mm to <20 mm seems to be the best site for embryo transfer to achieve higher PRs.
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.