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Review
. 2010 Feb;65(2):131-7.
doi: 10.1016/j.maturitas.2009.12.014. Epub 2009 Dec 30.

Midlife predictors of Alzheimer's disease

B B Bendlin  1 , C M Carlsson, C E Gleason, S C Johnson, A Sodhi, C L Gallagher, L Puglielli, C D Engelman, M L Ries, G Xu, W Wharton, S Asthana
Affiliations
Review

Midlife predictors of Alzheimer's disease

B B Bendlin et al. Maturitas. 2010 Feb.

Abstract

Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife.

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References

    1. International AD. World Alzheimer Report. 2009.
    1. Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, Burke JR, Hurd MD, Potter GG, Rodgers WL, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125–132. - PMC - PubMed
    1. Berr C, Wancata J, Ritchie K. Prevalence of dementia in the elderly in Europe. Eur Neuropsychopharmacol. 2005;15(4):463–471. - PubMed
    1. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med. 2009;360(22):2302–2309. - PubMed
    1. Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol. 2009;68(1):1–14. - PMC - PubMed

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