Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar;75(3):219-23.
doi: 10.1016/j.steroids.2009.12.002. Epub 2010 Jan 4.

Acute Exercise Activates Local Bioactive Androgen Metabolism in Skeletal Muscle

Affiliations

Acute Exercise Activates Local Bioactive Androgen Metabolism in Skeletal Muscle

Katsuji Aizawa et al. Steroids. .

Abstract

Androgens, such as testosterone, play important roles in regulation of diverse physiological process of target tissues. Recently, we reported that steroidogenic enzymes exist in skeletal muscle and regulate local production of testosterone in response to exercise. Testosterone is transformed into a bioactive androgen metabolite, dihydrotestosterone (DHT) by 5alpha-reductase. However, it is unclear whether exercise stimulates local bioactive androgen metabolism in the skeletal muscle in both sexes. In the present study, we examined sex differences in the levels of dehydroepiandrosterone (DHEA), free testosterone, DHT, and steroidogenesis-related enzymes 5alpha-reductase and androgen receptor (AR) in rat's skeletal muscle before and after a single bout of exercise. Basal muscular free testosterone and DHT levels were higher in males than females, whereas the levels of DHEA did not differ between the sexes. Muscular DHEA, free testosterone, and DHT levels were increased in both sexes after the exercise. There were no differences of 5alpha-reductase and AR transcripts and proteins between the sexes, and the expression of 5alpha-reductase was significantly increased in both sexes after the exercise. Finally, the expression of AR was significantly higher in female rats, but not in males after the exercise. These data suggest that acute exercise enhances the local bioactive androgen metabolism in the skeletal muscle of both sexes.

Similar articles

See all similar articles

Cited by 18 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback