Advances in proteomic technologies have led to the creation of large-scale proteome databases that can be used to elucidate invaluable information on the dynamics of the metabolic, signaling and regulatory networks and to aid understanding of physiological changes. In particular, proteomics can have practical applications, for example, through the identification of proteins that may be potential targets for the biotechnology industry, and through the extension of our understanding of the physiological action of these proteins. In this review, we describe proteomic approaches for the discovery of targets that have potential biotechnological applications. These targets include promoters, chaperones, soluble fusion partners, anchoring motifs, and excretion fusion partners. In addition, we discuss the potential applications of proteomic techniques for the design of future bioprocesses and the optimization of existing ones. Successful applications of proteomic information have proven to have enormous value for both scientific and practical applications.
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