Mass spectrometer for respiratory research

Respir Physiol Neurobiol. 2010 Feb 28;170(2):183-4. doi: 10.1016/j.resp.2009.12.013. Epub 2010 Jan 4.


The mass spectrometer is the ideal gas analyser for many applications in respiratory research. A number of companies which manufactured mass spectrometers suitable for use in respiratory research have long since ceased production. Two modifications in the presently manufactured MAX300-LG (Extrel, Pittsburgh, PA, USA) have made it suitable for studying respiratory physiology. The initial step was to bypass the four-port valve and connect the sampling capillary directly to the roughing pump. The second step was to replace the original capillary, which had an internal diameter of 0.4mm, by a 2-m long capillary having an internal diameter of 0.15 mm. The 90% response time was shortened to 85 ms, which is suitable for respiratory research.

MeSH terms

  • Calibration
  • Equipment Design
  • Humans
  • Mass Spectrometry / instrumentation*
  • Research / instrumentation
  • Respiratory Physiological Phenomena*