Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis

J Cyst Fibros. 2010 Mar;9(2):110-6. doi: 10.1016/j.jcf.2009.11.010. Epub 2009 Dec 31.


Background: Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF.

Methods: A CF cohort database was utilized to determine filamentous fungal prevalence and risk factors.

Results: The prevalence of filamentous fungal isolation increased from 2.0% in 1997 to 28.7% in 2007. The odds of isolating filamentous fungi during a quarter was greater in CF adults [p<0.001], during chronic oral antibiotic use [p=0.002] and increased with each 10% drop in FEV(1) percent predicted [p=0.005], while inhaled corticosteroids surprisingly decreased the likelihood [p=0.012]. The direction of these effects persisted after excluding individuals with ABPA. A sub-analysis determined older age [p=0.019] and use of inhaled antibiotics [p=0.011] were independent risk factors for onset of fungal colonization.

Conclusions: This study suggests that isolation of filamentous fungi in CF at JHH has increased and risk factors include older age, decreased lung function, and chronic oral antibiotics.

MeSH terms

  • Administration, Inhalation
  • Administration, Oral
  • Adrenal Cortex Hormones / administration & dosage
  • Adult
  • Age Factors
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Child
  • Cohort Studies
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis / microbiology*
  • Cystic Fibrosis / physiopathology
  • Databases, Factual
  • Drug Administration Schedule
  • Forced Expiratory Volume
  • Fungi* / isolation & purification
  • Humans
  • Mycoses / complications*
  • Mycoses / epidemiology*
  • Prevalence
  • Respiratory Function Tests
  • Retrospective Studies
  • Risk Factors


  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents