A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

Bioorg Med Chem. 2010 Feb;18(3):1273-9. doi: 10.1016/j.bmc.2009.12.029. Epub 2010 Jan 4.


A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Flavanones / chemical synthesis
  • Flavanones / chemistry*
  • Flavanones / pharmacology*
  • Flavones / chemical synthesis
  • Flavones / chemistry*
  • Flavones / pharmacology*
  • Humans
  • Models, Molecular
  • Monoamine Oxidase / chemistry
  • Monoamine Oxidase / metabolism*
  • Monoamine Oxidase Inhibitors / chemical synthesis
  • Monoamine Oxidase Inhibitors / chemistry*
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Stereoisomerism
  • Sulfhydryl Compounds / chemistry


  • Flavanones
  • Flavones
  • Monoamine Oxidase Inhibitors
  • Sulfhydryl Compounds
  • Monoamine Oxidase