Synthesis and Configurational Stability of (S)- And (R)-deuteriothalidomides

Chem Pharm Bull (Tokyo). 2010 Jan;58(1):110-2. doi: 10.1248/cpb.58.110.

Abstract

3'-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deuterium / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Teratogens / chemical synthesis
  • Teratogens / chemistry*
  • Thalidomide / chemical synthesis
  • Thalidomide / chemistry*

Substances

  • Teratogens
  • Thalidomide
  • Deuterium