Therapy: Hydroxychloroquine in SLE: old drug, new perspectives

Nat Rev Rheumatol. 2010 Jan;6(1):10-1. doi: 10.1038/nrrheum.2009.235.


Antimalarial agents have long been used in the treatment of autoimmune diseases, despite uncertainty regarding the exact mechanisms underlying their various effects. Growing evidence that these drugs offer protection from major infections could stimulate more research into these mechanisms, with possible implications for therapy.

Publication types

  • News

MeSH terms

  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Humans
  • Hydroxychloroquine / pharmacology
  • Hydroxychloroquine / therapeutic use*
  • Lupus Erythematosus, Systemic / drug therapy*


  • Antimalarials
  • Hydroxychloroquine