Hepatoprotective Activity of Ficus carica Leaf Extract on Rifampicin-Induced Hepatic Damage in Rats

Indian J Pharm Sci. May-Jun 2008;70(3):364-6. doi: 10.4103/0250-474X.43003.


Shade dried leaves of Ficus carica were extracted using petroleum ether (60-80 degrees ) and tested for antihepatotoxic activity on rats treated with 50 mg/kg of rifampicin orally. The parameters assessed were serum levels of glutamic oxaloacetate transaminase, glutamic pyruvic transaminase, bilirubin and histological changes in liver. Liver weights and pentobarbitione sleeping time as a functional parameter were also monitored. There was significant reversal of biochemical, histological and functional changes induced by rifampicin treatment in rats by petroleum ether extract treatment, indicating promising hepatoprotective activity.

Keywords: Ficus carica; hepatoprotectice activity; rifampicin-induced hepatic damage.