Diverse functions of perineuronal nets

Acta Neurobiol Exp (Wars). 2009;69(4):564-77. doi: 10.55782/ane-2009-1766.


Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet. Perineuronal nets may play a beneficial role by stabilizing the extracellular milieu assuring the characteristic features of enveloped neurons and protecting them from the influence of harmful agents. On the other hand, perineuronal nets create a barrier which limits neuronal plasticity and counteracts regeneration. This review examines recent evidence concerning the significance of the occurrence of perineuronal nets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / metabolism
  • Extracellular Matrix / ultrastructure
  • Mice
  • Nerve Net / anatomy & histology
  • Nerve Net / physiology*
  • Nerve Tissue Proteins / metabolism
  • Neurons / cytology
  • Neurons / metabolism*
  • Peripheral Nerves / cytology
  • Peripheral Nerves / physiology*
  • Rats


  • Nerve Tissue Proteins