Diffuse central nervous system protoplasmic astrocytoma

Pediatr Blood Cancer. 2010 May;54(5):768-9. doi: 10.1002/pbc.22402.


Protoplasmic astrocytoma is an extremely rare form of grade II low grade glioma which usually presents as a discrete mass lesion. We describe a 3-year-old female with diffuse protoplasmic astrocytoma with parenchymal involvement and leptomeningeal spread. This tumour proved extremely difficult to diagnose and followed a progressive course. Three superficial biopsies did not give the diagnosis and this was only confirmed 8 months from presentation from a larger fourth biopsy taken deeper from the cerebellum. To our knowledge this case represents the distinct presentation of protoplasmic astrocytoma presenting as extensive diffuse meningeal disease.

Publication types

  • Case Reports

MeSH terms

  • Astrocytoma / pathology*
  • Cerebellar Neoplasms / pathology*
  • Child, Preschool
  • Delayed Diagnosis
  • Diagnosis, Differential
  • Epilepsy, Tonic-Clonic / etiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Meningeal Neoplasms / pathology*
  • Photomicrography
  • Tuberculosis, Meningeal / diagnosis