Abstract
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.
MeSH terms
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Epigenesis, Genetic*
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Heterochromatin / genetics
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Heterochromatin / metabolism
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Histones / genetics
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Histones / metabolism
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Humans
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Janus Kinase 2 / genetics
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Janus Kinase 2 / metabolism*
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Leukemia / enzymology*
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Leukemia / genetics
Substances
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CBX5 protein, human
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Chromosomal Proteins, Non-Histone
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Heterochromatin
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Histones
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Chromobox Protein Homolog 5
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Janus Kinase 2