Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 11 (2), 124-36

Genetics of Mammalian Meiosis: Regulation, Dynamics and Impact on Fertility

Affiliations
Review

Genetics of Mammalian Meiosis: Regulation, Dynamics and Impact on Fertility

Mary Ann Handel et al. Nat Rev Genet.

Abstract

Meiosis is an essential stage in gamete formation in all sexually reproducing organisms. Studies of mutations in model organisms and of human haplotype patterns are leading to a clearer understanding of how meiosis has adapted from yeast to humans, the genes that control the dynamics of chromosomes during meiosis, and how meiosis is tied to gametic success. Genetic disruptions and meiotic errors have important roles in infertility and the aetiology of developmental defects, especially aneuploidy. An understanding of the regulation of meiosis, coupled with advances in genomics, may ultimately allow us to diagnose the causes of meiosis-based infertilities, more wisely apply assisted reproductive technologies, and derive functional germ cells.

Similar articles

See all similar articles

Cited by 168 articles

See all "Cited by" articles

References

    1. Mol Biol Cell. 2005 Dec;16(12):5804-18 - PubMed
    1. Mol Cell. 2000 Nov;6(5):975-87 - PubMed
    1. Development. 2009 Mar;136(6):965-73 - PubMed
    1. PLoS Genet. 2009 Oct;5(10):e1000702 - PubMed
    1. Nat Genet. 2005 Dec;37(12):1351-5 - PubMed

LinkOut - more resources

Feedback