Scribble at the crossroads

J Biol. 2009;8(12):104. doi: 10.1186/jbiol190. Epub 2009 Dec 29.


Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Polarity / physiology*
  • Cell Proliferation*
  • Drosophila Proteins / physiology
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / physiology*


  • Drosophila Proteins
  • Tumor Suppressor Proteins