Nature of the endogenous pyrogen (EP) induced by influenza viruses: lack of correlation between EP levels and content of the known pyrogenic cytokines, interleukin 1, interleukin 6 and tumour necrosis factor

J Gen Virol. 1991 Mar;72 ( Pt 3):705-9. doi: 10.1099/0022-1317-72-3-705.


Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret of human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines.

MeSH terms

  • Animals
  • Biological Assay
  • Ferrets
  • Fever / etiology
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / physiology
  • Interleukin-6 / biosynthesis
  • Interleukin-6 / physiology
  • Leukocytes / immunology*
  • Orthomyxoviridae / physiology*
  • Orthomyxoviridae Infections / metabolism
  • Pyrogens / biosynthesis*
  • Pyrogens / physiology
  • Sonication
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / physiology


  • Interleukin-1
  • Interleukin-6
  • Pyrogens
  • Tumor Necrosis Factor-alpha
  • leukocyte endogenous mediator